Serotonin Is Both a Biomarker and Driver of Osteoporosis

Story at-a-glance

• Osteoporosis is driven by stress-related chemical signals, not just calcium loss, and these signals begin weakening bone years before fractures appear
• Elevated serotonin in your bloodstream acts as a hormone that directly accelerates bone breakdown while suppressing bone repair
• Women further past menopause show higher serotonin-related markers and faster progression toward osteoporosis, even when mineral levels look normal
• Stress hormones triggered by excess serotonin create a biological environment that dismantles bone to meet perceived survival demands
• Calming stress chemistry through sleep, nutrition, digestion, and gentle strength work shifts bone signaling from breakdown toward preservation

You're taking your calcium. You're doing weight-bearing exercise. Your doctor says your bone scan "looks fine for your age." Then one day you sneeze, turn the wrong way, or trip on a curb — and your wrist shatters. The ER doctor tells you it's osteoporosis, but here's what no one answered: what was actually happening inside your bones for the past decade while your scans still looked acceptable.

                              Analysis by Dr. Joseph Mercola

 

        A SHOCKER ABOUT NON-STICK PANS.😖

                              THE END!

 

Preservatives in Ultraprocessed Food Linked to Rising Cancer and Diabetes Rates

Story at-a-glance

• Before refrigeration, humans preserved food through drying, fermenting, curing, and pickling. These methods helped extend food availability without synthetic chemicals
• Industrialization drove the use of chemical preservatives like nitrites, sulfites, and sodium benzoate, enabling mass distribution while dramatically increasing synthetic additives in the modern food supply
• U.S. food regulations allow hundreds of additives that are banned in Europe, with loopholes that permit manufacturers to omit some ingredients from labels, limiting consumer awareness and informed choice
• Studies link higher preservative intake to increased cancer and Type 2 diabetes rates, showing dose-dependent risk independent of calories, weight, or overall diet quality
• Biological mechanisms include DNA damage, inflammation, microbiome disruption, hormonal interference, and insulin resistance, reframing preservatives as cumulative risk factors rather than ingredients that simply extend shelf life

Long ago, before refrigeration was invented, early humans preserved their food in different ways. One of the most common methods is drying meat, fruit, and vegetables under the sun. Pickling, curing, and fermenting were also used, depending on a particular culture's practices. All the same, the goal was to prevent their food supply from spoiling so that they didn't have to consume them immediately. 

                                               Analysis by Dr. Joseph Mercola

 

Seed Oils Linked to Early 20th Century Heart Disease Surge

Story at-a-glance

• My paper, Seed Oils as a Hypothesized Contributor to Heart Disease: A Narrative Synthesis, explains that heart disease was rare before the 20th century and surged only after industrial seed oils became a dominant part of the food supply, pointing to a long-term dietary driver rather than sudden biological failure
• Linoleic acid (LA) from seed oils accumulates in your tissues and oxidizes easily, creating inflammatory damage inside arteries that builds silently for decades before symptoms appear
• The rise in seed oil consumption preceded the explosion in heart disease by 10 to 20 years, matching the slow timeline of plaque formation inside blood vessels
• Even if you avoid seed oils at home, LA remains embedded in packaged foods and restaurant meals, creating constant exposure that keeps arterial damage ongoing
• Tracking and reducing LA intake transforms heart disease from an inevitable outcome of aging into a long-term process you can influence

Heart disease feels like a permanent feature of modern life, but it wasn't always that way. In the late 1800s, coronary heart disease was uncommon, and most people died from infections rather than chronic vascular problems. Today, coronary heart disease sits at the center of cardiovascular mortality, bringing with it chest pain, breathlessness, fatigue, and sudden heart attacks that often appear after years of silent damage.

Analysis by Dr. Joseph Mercola

 

How Incorporating Fermented Foods Into Meals Supports Gut Health

Story at-a-glance

• Fermented foods help reshape your gut environment by delivering beneficial microbes and fermentation byproducts that support digestion, immune balance, and nutrient absorption
• Regular intake of fermented foods has been linked to lower levels of inflammatory proteins tied to chronic conditions such as metabolic dysfunction, joint discomfort, and stress-related health issues
• The fermentation process breaks down difficult-to-digest compounds in foods, which helps reduce bloating, improves food tolerance, and supports a stronger intestinal barrier
• Not all foods labeled fermented provide meaningful benefits, as pasteurization, vinegar acidification, and heavy processing often reduce or eliminate the biological compounds that support gut health
• Small, consistent servings of traditionally prepared fermented foods — especially when they replace processed foods — help restore microbial diversity and strengthen long-term digestive resilience

If you've tried probiotics without relief, cut out foods that still cause bloating, or wonder why your digestion hasn't quite recovered after antibiotics, the missing piece might not be what you're avoiding — it's what traditional diets included daily that yours doesn't. Fermented foods aren't supplements. They're how food was prepared before modern processing stripped away the microbial activity your gut evolved to expect.

Analysis by Dr. Joseph Mercola

 

Statins, Cholesterol, and the Real Cause of Heart Disease

Story at-a-glance

Despite decades of statin use costing approximately $25 billion annually in America alone, heart disease remains the leading cause of death, suggesting the cholesterol hypothesis that drives statin prescriptions is fundamentally flawed

Studies show that lowering cholesterol with statins does not reduce heart disease, and yet these findings are ignored while statin guidelines are created by experts paid by pharmaceutical manufacturers

Malcolm Kendrick’s clotting model provides a superior explanation for heart disease: atherosclerotic plaques result from repeated damage to blood vessel linings which the body repairs with layers of clots

The medical establishment dismisses widespread reports of statin injuries as “nocebo effects,” paralleling how COVID-19 vaccine injuries were dismissed as “anxiety,” despite extensive evidence corroborating the injuries

The actual causes of heart disease — fine particulate matter from pollution and cigarettes, lead exposure, chronic stress, and endothelial damage — receive minimal research funding because effective interventions cannot be patented and sold as expensive pharmaceuticals like statins

Frequently in science, fundamental facts are altered to create a profitable industry. Recently, I showed how this occurs with blood pressure: rather than causing arterial damage, high blood pressure is a response to arterial damage that ensures damaged arteries can still deliver blood to the tissues.

In turn, rather than helping patients, aggressively lowering blood pressure can be quite harmful. In this article, I will look at the other half of the coin, statins, cholesterol, and heart disease — something that harms so many Americans, it was poignantly discussed by Comedian Jimmy Dore. The link is 

https://twitter.com/i/status/1833908586927501550

Analysis by A Midwestern Doctor

 

Evidence Points to a Narrow Exercise Range That Protects Metabolism and Cognition

Story at-a-glance

• Walking 5,001 to 7,500 steps a day slows the buildup of tau, the brain protein linked to Alzheimer’s-related decline, helping you stay sharper for years longer
• Older adults with elevated amyloid — a key early Alzheimer’s marker — preserved memory and daily function far better when they consistently reached a moderate step range
• Even small increases in movement, such as moving from under 3,000 steps to 3,500 to 5,000 per day, deliver meaningful cognitive benefits without requiring intense exercise
• High-intensity training pushed healthy adults into metabolic dysfunction, reducing mitochondrial energy production by about 40% and disrupting blood sugar stability
• Finding your personal exercise “sweet spot” — enough movement to avoid inactivity without pushing into extreme training — protects both long-term brain health and daily metabolic balance

Alzheimer's disease quietly takes hold decades before the first forgotten appointment or misplaced word triggers concern. It's a disorder characterized by memory loss, confusion, shifts in personality, and a gradual erosion of independence, and when it progresses unchecked, it leads to severe cognitive decline and total reliance on others.

Analysis by Dr. Joseph Mercola

Analysis by Dr. Joseph Mercola

 

Forever Chemicals' Linked to Threefold Higher Liver Disease Risk in Adolescents

Paste this link for the You Tube Video

                                                           https://youtu.be/HZbRgfVcBWA

                                                                            OR

                                                          ORDER IT FROM AMAZON

 

America's Favorite Cooking Oil Shows Strong Link to Obesity

Story at-a-glance

• Soybean oil dominates the U.S. food supply. Americans’ intake has increased from about 2% to nearly 10% of calories over a century, alongside sharp rises in obesity and diabetes
• A recent study published in the Journal of Lipid Research found soybean oil drives obesity independent of calories by generating liver oxylipins that track with weight gain, revealing LA metabolism, not food intake, as the key driver of fat accumulation
• Soybean oil promotes oxidative stress, mitochondrial damage, gut permeability, and long-lasting inflammatory byproducts that continue to affect your metabolism for years due to LA’s extended half-life in body fat
• Soy contains additional disruptive compounds, including phytoestrogens, phytic acid, enzyme inhibitors, lectins, saponins, and goitrogens, along with frequent glyphosate residues
• Reducing LA intake means eliminating sources of soybean and other vegetable oils from your diet, and replacing them with stable fats like ghee, tallow, butter, or coconut oil

From restaurant meals to packaged staples, soybean oil is almost everywhere in the modern diet. In the United States, it's the most widely consumed oil, with intake climbing from roughly 2% of total calories to nearly 10% over the last century.1 During this period, adult obesity has surged to more than 42%, while Type 2 diabetes and other metabolic disorders have increased in parallel.

Analysis by Dr. Joseph Mercola

 

Gut Cure: How to Heal Your Microbiome and Reclaim Your Health from the Inside Out

Story at-a-glance

• My newest book, “Gut Cure: Stop the Rot, Restore Your Body From the Inside Out,” which comes out tomorrow, puts the spotlight on the modern epidemic of invisible gut dysfunction, and offers you a roadmap to true restoration
• Your gut microbiome acts as a command center for digestion, immunity, metabolism, and brain health; when microbial diversity drops, symptoms often go beyond digestion
• Short-chain fatty acids (SCFAs), especially butyrate, are essential compounds made by healthy gut bacteria that help repair your gut lining, calm inflammation, stabilize blood sugar, and support mental clarity
• Modern diets heavy in seed oils (including linoleic acid), emulsifiers, and ultraprocessed foods disrupt beneficial bacteria and reduce butyrate production, leaving your gut undernourished even if you eat “healthy” foods
• Simple changes, such as replacing seed oils with stable fats like butter, ghee, or coconut oil, can lower inflammation, rebalance your microbiome, and help your body begin healing from the inside out

You're active. You eat clean. You check ingredient labels, drink protein shakes, and track your macros. By all appearances, you're doing everything right. But deep down, something still feels off. You crash midafternoon, battle unexplained bloating, or struggle with joint pain that seems too stubborn for your age. You've tried taking supplements or changing your diet. So why are the symptoms still there?

Analysis by Dr. Joseph Mercola

 

Butyrate — A Tiny Molecule with Big Potential for Health and Healing

• Butyrate is a short-chain fatty acid (SCFA) produced when gut bacteria ferment dietary fiber. It provides energy for colon cells and offers health benefits beyond basic nutrition
• Research suggests butyrate helps manage inflammatory bowel disease (IBD) by reducing inflammation, improving symptoms and strengthening gut barrier integrity
• Laboratory studies show butyrate helps inhibit cancer cell growth and trigger cell death in colorectal cancer cells, with clinical trials exploring its use alongside traditional treatments
• Butyrate has been shown to improve insulin sensitivity and glucose metabolism in metabolic disorders, while also influencing appetite-regulating hormones
• Studies show butyrate protects against neurodegenerative diseases by reducing brain inflammation and enhancing neuronal repair and survival.

Butyrate is a short-chain fatty acid (SCFA) produced in your gut when beneficial bacteria ferment dietary fiber, which your body cannot digest on its own.

As the primary energy source for colonocytes (the cells lining your colon), butyrate provides up to 70% of their energy needs.1 However, its benefits go far beyond just fueling those cells — it also reduces inflammation, strengthens your gut barrier and supports immune system balance.2 These properties make butyrate a promising molecule for managing a wide variety of conditions and improving overall health.

Analysis by Dr. Joseph Mercola

 

The Keto HDAC Myth — How One Paper Misled Millions for a Decade

Story at-a-glance

• A 2013 Science paper claimed beta-hydroxybutyrate (BHB), the primary ketone body produced during ketosis, was a potent histone deacetylase (HDAC) inhibitor with powerful epigenetic benefits — this claim became the foundation of the keto movement's health narrative
• A devastating 2019 head-to-head comparison in Scientific Reports found that BHB shows no detectable HDAC inhibition in vitro or in vivo, while butyrate (a different molecule produced by gut bacteria) demonstrates robust HDAC-inhibiting activity
• The bitter irony: ketogenic diets actually reduce colonic butyrate production by depleting fiber intake and diminishing butyrate-producing gut bacteria — the very diet designed to boost the "HDAC-inhibiting ketone" may be depleting the actual HDAC inhibitor
• While BHB has legitimate benefits as an alternative fuel source and GPR109A receptor activator, the widespread claim that ketosis provides "epigenetic therapy" through HDAC inhibition appears to be scientifically unfounded
• Oral butyrate supplements are largely ineffective because butyrate is absorbed in the small intestine before reaching the colon where it's needed — currently, no commercially available product effectively delivers butyrate to the colon

For the past decade, the ketogenic diet community has promoted a compelling narrative: that entering ketosis produces beta-hydroxybutyrate (BHB), which acts as a powerful histone deacetylase (HDAC) inhibitor, unlocking profound epigenetic benefits that explain many of the diet's purported health advantages.

Analysis by Dr. Joseph Mercola

 

How Urolithin A Drives Mitochondrial Renewal and Slows Immune Aging

Story at-a-glance

• As you age, your thymus produces fewer newly formed cells responsible for responding to unfamiliar pathogens, reducing your immune system's adaptability. This shift, combined with persistent inflammation, defines the core features of immune aging
• Urolithin A, a postbiotic compound, stimulates mitochondrial renewal in aging immune cells. A recent study shows it can increase naïve-like T cells and strengthen immune surveillance in just four weeks of supplementation
• Clinical findings show that urolithin A boosts mitochondrial renewal pathways, increases markers linked to mitochondrial biogenesis, and improves immune cell metabolism
• Beyond immune health, studies reveal that urolithin A influences cancer pathways, enhances muscle strength and endurance, improves fatty liver markers, and reshapes metabolic signaling involved in obesity and insulin resistance
• Beyond using urolithin A, you can also support your mitochondria by lowering linoleic acid intake, eating the right carbohydrates, limiting environmental toxins, and supporting NAD⁺ production with niacinamide.
• 
  

• Most people tend to think of immune health mainly as a defense against seasonal colds or infections. In reality, its influence runs deeper. A well-balanced immune system helps regulate inflammation, maintain internal stability, and support energy and vitality. As the years pass, however, the immune system undergoes natural changes that are part of the aging process itself.1

Analysis by Dr. Joseph Mercola

 

     

New Data Connects Smartphone Ownership at Age 12 to Obesity and Mental Health Concerns

Story at-a-glance

• Early smartphone ownership at age 12 is linked to higher risks of depression, obesity, and insufficient sleep, placing your child on a riskier long-term developmental path
• Each year earlier a child receives a smartphone increases the odds of obesity and insufficient sleep, showing just how much the timing of that first phone shapes their health
• Children who acquire a smartphone between ages 12 and 13 face sharply higher rates of emotional symptoms and poor sleep compared to peers who remain phone-free
• Receiving a smartphone before age 13 is linked to lower self-worth, weaker emotional resilience, and greater psychological distress in young adulthood
• Simple steps like delaying smartphone access, keeping devices out of bedrooms, and reducing wireless exposure support healthier sleep, emotional steadiness, and long-term well-being

Twelve-year-olds in the U.S. live in a world where smartphone access feels almost unavoidable, yet the decision to give a device at this age carries far more weight than some parents realize. Many families assume that a phone is simply a tool for convenience or safety, but the emerging data signals something deeper: early access shapes how your child sleeps, handles stress, and interprets their social world.

Analysis by Dr. Joseph Mercola

                         YOU ARE MY ANCHOR 💓

     Yesterday I said that to my wife, partner and love of my life.

      During one of my sleepless sessions, I thought about something that happened some fifty years ago.

     We were teaching in Tatitlek a Chugash Indian village located in Prince Willam Sound, where the town of Valdez is located.

     One day I noticed from my window, which had a view of the dock, an Alaska State trooper disembarking from a skiff (small boat). I wondered who got into trouble in the village?

     A little while later, I got the answer, as the trooper was knocking on our door! It was for me. A gift from my ex-wife and her new husband, one of our neighbors! 

     Since we were twenty or so miles from Valdez, I had to take my skiff and head in to be able to respond to the summon.

     This was in the middle of winter, a very hazardous time to be travelling in a small twenty foot skiff!

      The trip in was luckily not bad at all. The weather was good.😃 I went in, spent the night and took care of business from a friend's house, the Londagins. 

       The  following day, I headed back home to Tatitlek. The weather had taken a turn to the worse. The winds were severe. However when looking at the water from the citydock,  it wasn't that bad. The skiff wouldn't have a problem. Off I went. 💪

     When I went through the Narrows and entered into the Sound a short distance, the wind turned violent. (gulp!)

     

Valdez is at the top portion of the picture, Bligh Reef is where I anchored after entering the Sound. The break in the land is where I anchored for the night to wait out the weather. The winds had developed huge breakers around Bligh Reef, the entrance into the Tatitlek Narrows to home.

     I knew that if I decided to try to go adound the reef, I more than likely would NOT make it. I pulled into the anchorage and dorpped anchor. I spent the night and in the morning, the wind had subsided - home I went to my loved one!😉 I am actualy visiluizing this trip as I write.

     My hope is that I can return the favor an be HER ANCHOR for the tough times.😀

     

     

                                                     WHAT IS LOVE 💓?

     After 61 years of being HAPPILY married, I think I AM qualified enough to give you my rendition of what happens when you are fortunate to have the necessary qualities.

     The onset of ROBOT production is trying to mimic human behavior, mechanically. The brain is an electrically controlled by an mechanical instument, called a computer. It conrols all of its robotic functions. However it cannot FEEL love. It might only mimic it, as we humans sometimes do.😔 It appears that it might be succesful. C'est la vie, of a robot.

     The actions of a human are also controlled by an electical system, composed of organic material, called the brain. It posseses the necessary information to control ALL of its bodily function.

     Since we are electronically controlled, we have both postive and negative charges. The law states that like charges repel and opposite charges attract. Now that expalins the polarity difference between male and female bodies. (I could'nt designate the plus  nor the minus sign for them because I am NOT stupid!)

     If there is a polarity problem in the brain then you will get a disorder in that body's brain without changing the body's (two completely different systems.)

     Love is an emotional situation (heart 💓, feeling love) and also a physical (making love,( sex)) both expressed differently. Vive la diffe*rence! (I couldn't put the proper accent on the first E.)😒

     When through the passage of time (old age) or a problem (disease) happens, an ANXIETY SYNDROME comes into play. It will change the polarity within the brain from what it was. That is a huge PROBLEM for the person.😕

     THE problem is, how does the loved one, handle that situation?😕

      I can tell you from experience,😒 I think the only solution is to be lovingly 💓 understanding and very sympathetic 💞 toward your partner. 

        (A little praying probably would'nt hurt.)

 

High Ultraprocessed Food Intake Linked to Lower DNA Methylation

• A study of 30 adult women revealed those consuming 45% of their daily calories as ultraprocessed foods showed hypomethylation in 80 genome regions, affecting genes linked to fat storage, insulin sensitivity, and cancer progression
• Research on 3,152 European children found that ultraprocessed food consumption caused consistent DNA methylation changes affecting thyroid function, liver health, DNA repair, and stress-response genes
• Methylation changes occur even in healthy-weight individuals, demonstrating that genetic damage accumulates years before traditional metabolic markers like blood sugar, cholesterol, or body fat show problems
• Breaking ultraprocessed food addiction requires restocking your pantry with whole foods, adding protein and fiber to 
• meals, reading ingredient labels carefully, and building supportive communities focused on healthier eating.

• 
  

• Food is a cornerstone of health, and the healthier your choices are, the healthier you'll be. However, the modern Western diet, which is filled with ultraprocessed food, is anything but healthy. These products are made with synthetic ingredients that ultimately drive chronic disease.

• Now, a new study goes into the mechanisms of ultraprocessed foods, and the findings are shocking. Researchers found that these products reshape your body at the genetic level by rewriting biological instructions, silencing protective genes and activating harmful ones, and basically creating cellular chaos.

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Analysis by Dr. Joseph Mercola

 

I am changing what I do. I will provide the link to an article that is interesting   Just click the  link and paste itmin your browser.

 https://youtu.be/UnhT77W9mtQ?t=6201

Why Antidepressants Aren’t Fixing Depression — and How the System Keeps That Truth Buried

 

How Metabolic Health and Inflammation Influence Cancer Risk

Story at-a-glance

• Chronic inflammation and broken metabolism create the conditions that allow cancer cells to grow, spread, and overwhelm your body’s natural defenses
• Stress hormones like cortisol block glucose use and flood your system with fatty acids, forcing your cells into a backup energy mode that fuels tumors
• A combination of vitamins B1, B3, and B7 restored clean energy production in lab models, stopping tumor growth and showing promise for shifting metabolism back toward health
• Adding aspirin to this vitamin trio moved tumors from remission to complete disappearance in animal studies, with historical evidence showing these doses can be used safely
• Simple daily choices — such as reducing seed oils, supporting vitamin D, calming gut inflammation, and balancing hormones — help lower chronic stress signals and protect long-term health

Cancer doesn't appear out of nowhere — it develops in an environment your body has been shaping for years. One of the most overlooked factors is the way everyday stressors gradually push your system out of balance. When your body is constantly under pressure, the signals that control repair, growth, and immunity start working against you instead of for you.

You might not notice it at first. A little more tired than usual, a few pounds gained or lost without explanation, aches that seem to linger — these are all signs your body is stuck in a cycle of strain. Left unchecked, this state doesn't just wear you down, it lays the groundwork for serious disease.

Analysis by Dr. Joseph Mercola

 

A Deep Dive Into Butyrate — Your Gut’s Powerhouse Molecule

Story at-a-glance

• Butyrate is a short-chain fatty acid (SCFA) produced by gut bacteria that ferment dietary fiber. It serves as essential fuel for colon cells and maintaining overall systemic health
• Adequate fiber intake — around 30 grams daily — is crucial for butyrate production. Without it, your body burns stored fat and protein, creating disease-causing byproducts
• Butyrate strengthens your gut barrier, preventing intestinal permeability that allows harmful substances to enter the bloodstream and trigger autoimmune responses
• Research shows butyrate improves insulin sensitivity, reduces diabetes risk, lowers bad cholesterol, prevents colorectal cancer, and supports brain health
• Boost butyrate by eating fiber-rich foods, resistant starches, fermented foods and probiotics, while avoiding processed foods, managing stress, and limiting unnecessary antibiotics

Gut health is a cornerstone for optimal wellness, and one aspect of it that deserves more attention is butyrate. In a presentation titled "Butyrate: The Key to Optimal Health and Well-Being,"1 Indiana-based dietitian Dawn Boxell takes a deep dive into the importance of this crucial molecule, which is a topic I'm also passionate about.

Please watch YouTube video:

https://articles.mercola.com/sites/articles/archive/2026/01/19/deep-dive-into-butyrate-guts-powerhouse-molecule.aspx?ui=2ce50f7b7b2c7e6a19036c1284fe1fe390cd9ed962c31382e75e2db3ca24d4bb&sd=20130819&cid_source=wnl&cid_medium=email&cid_content=art1ReadMore&cid=20260119Z1&foDate=true&mid=DM1870911&rid=482868240

Analysis by Dr. Joseph Mercola

 

Stress Alters Metabolic Hormone with Health Consequences, Study Shows

Story at-a-glance

• Research from Columbia University shows that psychological stress changes a key metabolic hormone, linking emotional strain directly to energy production and overall health
• People with healthy mitochondria experience a drop in this hormone under stress, while those with mitochondrial dysfunction show an increase — demonstrating how cellular energy capacity shapes stress resilience
• Chronic stress overstimulates classic stress hormones like cortisol and adrenaline, disrupting blood sugar control, promoting fat storage, and exhausting your mitochondria — the engines that power every cell
• Social isolation and loneliness were linked to higher levels of stress-related hormones, suggesting that emotional well-being and physical metabolism are deeply connected
• Restoring mitochondrial balance through nutrition, regular movement, deep sleep, and meaningful connection helps calm stress chemistry, boost energy, and slow biological aging

Stress doesn’t just live in your head — it reshapes your entire body. Every time you feel anxious, overworked, or emotionally strained, your cells react. Hormones shift, energy production slows, and inflammation rises. Over time, those invisible reactions create measurable wear and tear that affects how quickly you age, how well you recover, and even how clearly you think.

Your mitochondria — the tiny power plants in your cells — sit at the center of this process. When they function well, you feel alert, resilient, and balanced. But when they falter, everything suffers. Energy crashes. Hormones go haywire.

Analysis by Dr. Joseph Mercola